Thabo Mbeki was the executive face of government in South Africa from 1994. During his time in office the economy grew at an average rate of 4.5% per annum. Mbeki created employment in the middle sectors of the economy and oversaw a fast growing black middle class with the implementation of BEE. This growth exacerbated the demand for trained professionals strained by emigration due to violent crime, but failed to address unemployment amongst the unskilled bulk of the population. He attracted the bulk of Africa’s Foreign Direct Investment (FDI) and made South Africa the focal point of African growth. He was the architect of NEPAD whose aim is to develop an integrated socio-economic development framework for Africa. He also oversaw the successful building of economic bridges to BRIC (Brazil, Russia, India and China) nations with the eventual formation of the India-Brazil-South Africa (IBSA) Dialogue Forum to "further political consultation and co-ordination as well as strengthening sectoral co-operation, and economic relations".

Mbeki has mediated in difficult and complex issues on the African continent including Burundi, Democratic Republic of Congo (DRC), the Ivory Coast, and some important peace agreements. He oversaw the transition from the Organisation of African Unity (OAU) to the African Union (AU). His 'quiet diplomacy' in Zimbabwe, however, is blamed for protracting the survival of Robert Mugabe's regime at the cost of thousands of lives and intense economic pressure on Zimbabwe's neighbours. He became a vocal leader of the Non-Aligned Movement in the United Nations and while leveraging South Africa's seat on the Security Council, agitating for reform of the Security Council.

Mbeki has received worldwide criticism for his AIDS stance. He questions the link between viruses and AIDS and believes that the correlation between poverty and the AIDS rate in Africa was a challenge to the viral theory of AIDS. His fate was not helped by Health Minister Manto Tshabalala-Msimang and the overhaul of the pharmaceutical industry in South Africa. The delay in distributing antiretroviral drugs is attributed to the ban he placed on their use in public state hospitals, and is also linked to the estimated deaths of some hundreds of thousands. Thabo Mbeki has also been criticized for responding on negative comments made about governance by accusing them of racism.

Born and raised in Idutywa (Transkei), what is now the Eastern Cape province of South Africa, Mbeki is one of four children of Epainette and Govan Mbeki. His father was a stalwart of the African National Congress (ANC) and the South African Communist Party. He is a native Xhosa speaker. His parents were both teachers and activists in a rural area of ANC strength, and Mbeki describes himself as "born into the struggle"; a portrait of Karl Marx sat on the family mantelpiece, and a portrait of Mohandas Gandhi was on the wall.

Mbeki attended primary school in Idutywa and Butterworth and acquired a high school education at Lovedale, Alice. In 1959, he was expelled from school as a result of student strikes and forced to continue studies at home. In the same year, he sat for matriculation examinations at St. John's High School, Umtata. In the ensuing years, he completed British "A" levels examinations and undertook an economics degree as an external student with the University of London. During this time, the ANC was banned and Mbeki was involved in underground activities in the Pretoria-Witwatersrand area. He was also involved in mobilising students in support of the ANC call for a stay at home to be held in protest of South Africa becoming a republic.

In December 1961, he was elected secretary of the African Students' Association. In the following year, he left Africa on instructions of the ANC.

Govan Mbeki had come to the rural Eastern Cape as a political activist after earning two university degrees; he urged his family to make the ANC their family, and of his children, Thabo Mbeki is the one who most clearly followed that instruction, joining the party at age 14 and devoting his life to it thereafter.

Mbeki married his wife Zanele (née Dlamini) at Farnham Castle, in the United Kingdom, in 1974.

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